Serum Tumour Markers: Implications of Discordant Results

Appropriate requesting of serum tumour markers.

marker’s serum concentration.1 Likewise, non-malignant liver disease can cause rises in both CEA and CA19.9.2 This patient was not as widely investigated as a previous case of raised CA125 presented in the BMJ, in which a further diagnostic laparoscopy, mammography, and oral gastroduodenoscopy was performed in a patient with ascites due to hypothyroidism.3 Because of these and other limitations...

Serum tumour markers in malignant mesothelioma

Malignant mesothelioma is a rare malignancy of the body cavities with dismal prognosis. It has been a diagnostic dilemma for years with many clinical and pathological mimics. Discovery of a reliable tumour marker will MESOTHELIN RELATED Pallavi Rao, Srikanth PEPTIDE Narayanaswamy Derriford Hospital, Plymouth, United Mesothelin is a glycophosphatidylinKingdom ositol anchored glycoprotein, which ...

Commercial assays for serum osteocalcin give clinically discordant results.

Serum samples from 9 healthy controls and from subjects with primary hyperparathyroidism (n = 5), Paget disease (n = 3), pregnancy (n = 5), glucocorticoid therapy (n = 5), postmenopausal osteoporosis (n = 10), and renal failure (n = 10) were used to assess the clinical agreement among eight commercially available assay kits for osteocalcin (OC). These kits differ in their assay configurations (...

Serum tumour markers: how to order and interpret them.

Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.

BACKGROUND The FibroTest and ActiTest are noninvasive biochemical markers of liver injury that are intended for use as alternatives to liver biopsy in patients with chronic hepatitis C. The aims of this study were to assess the quality of biopsy and the prevalence of discordances between biopsy and markers, to identify factors associated with discordances, and to attribute these discordances to...